be male

have an age of 18 years or older

be biopsy naïve

have a clinical suspicion of prostate cancer

be scheduled for evaluation by prostate MRI based on a suspicious DRE and/or elevated serum PSA

have signed informed consent

active (urinary tract) infection or prostatitis

a patient history with a cardiac right-to-left shunt.

allergic to sulphur hexafluoride or any of the other ingredients of the ultrasound contrast agent SonoVue

current treatment with dobutamine

known severe pulmonary hypertension (pulmonary artery pressure \>90 mmHg), uncontrolled systemic hypertension or respiratory distress syndrome

any (further) contraindication to undergo MRI or 3D mpUS imaging

incapable of understanding the language in which the patient information is given.

medical history of prostate surgery

treatment of 5 alpha-reductase inhibitors for at least 3 months