Voluntary participation, sign the informed consent with good compliance.

Age between 18-80 years.

ECOG performance status of 0 or 1; expected survival of at least 3 months.

Meeting all criteria for one of the following cancer types: * Renal Clear Cell Carcinoma: 1. Pathologically and radiologically confirmed metastatic or unresectable advanced clear cell renal cell carcinoma. 2. Failure after at least one systemic treatment for advanced or metastatic disease (including chemotherapy, targeted therapy, immunotherapy). 3. At least one measurable lesion (RECIST 1.1). * Urothelial Carcinoma: 1. Pathologically and radiologically confirmed metastatic or unresectable advanced urothelial carcinoma (including bladder, ureter, renal pelvis, and urethra). 2. Failure or refusal to receive at least one systemic chemotherapy for advanced, recurrent/metastatic disease. 3. Progression after one PD-1/PD-L1 inhibitor treatment. 4. At least one measurable lesion (RECIST 1.1). * Prostate Cancer: 1. Pathologically confirmed mCRPC with radiologically confirmed bone metastases or soft tissue metastases. 2. Failure after at least one novel endocrine treatment for metastatic disease (including but not limited to abiraterone, enzalutamide). 3. Failure or refusal of systemic chemotherapy. 4. Baseline serum testosterone \< 50 ng/dL (1.73 nmol/L). 5. For participants without baseline soft tissue target lesions, baseline serum PSA ≥ 2 ng/mL and meeting PSA disease progression criteria per PCWG3.

Adequate major organ function, laboratory test criteria: * Hematology: 1. Hemoglobin (HB) ≥ 90 g/L. 2. Absolute Neutrophil Count (ANC) ≥ 1.5×109/L. 3. Platelets (PLT) ≥ 75×109/L. * Biochemistry: 1. Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) ≤ 3 × ULN (≤ 5 × ULN for liver/bone metastasis). 2. Total Bilirubin (TBIL) ≤ 1.5 × ULN. 3. Serum Creatinine ≤ 1.5×ULN or Creatinine Clearance ≥ 30 mL/min. * Coagulation: * Activated Partial Thromboplastin Time (APTT), International Normalized Ratio (INR), Prothrombin Time (PT) ≤ 1.5×ULN.

Fertile women must agree to contraception during the study and for 3 months after the last administration of the study drug.

\[Failure Definition: Disease progression during treatment or after the last treatment, or intolerable toxicity due to side effects during treatment. Prior neoadjuvant or adjuvant treatment is allowed. If disease relapse or progression occurs within 6 months after the end of neoadjuvant/adjuvant treatment, it is considered a failure of first-line treatment for progressive disease.\]

Primary pure neuroendocrine cancer (except post-treatment neuroendocrine differentiation).

Other antitumor treatments within 4 weeks or 5 half-lives (whichever is shorter) before the start of the study treatment (except androgen deprivation therapy for prostate cancer patients, such as LHRH agonists or antagonists, bicalutamide, flutamide, etc.), or not yet recover from the toxicity of previous treatments (except ≤ G1 adverse events or tolerable G2 alopecia, fatigue/asthenia, and neuropathy caused by trauma at baseline).

Concurrent diseases/history:

Clinically significant hemoptysis (\> 50 mL per day) within 3 months before enrollment; significant clinical bleeding symptoms or clear bleeding tendency, such as gastrointestinal bleeding, bleeding gastric ulcers, baseline fecal occult blood and above.

Arteriovenous thrombotic events within 6 months before enrollment, such as cerebrovascular accidents (including transient ischemic attacks), deep vein thrombosis (except venous thrombosis caused by previous chemotherapy with venous catheterization judged by the investigator as cured), and pulmonary embolism.

Hypertension not well controlled with stable dose antihypertensive treatment (systolic pressure \> 150 mmHg or diastolic pressure \> 100 mmHg); myocardial infarction, severe/unstable angina, NYHA class 2 or above heart failure, clinically significant supraventricular or ventricular arrhythmias, prolonged QT interval, and symptomatic congestive heart failure within 6 months before baseline/screening.

Interstitial lung disease, non-infectious pneumonia, and other non-specific pneumonias (e.g., pulmonary fibrosis, interstitial pneumonia).

Active infection requiring antibiotic treatment within 4 weeks before the first administration of the study drug, or unexplained fever \> 38.5°C during screening or before the first administration of the study drug (fever due to tumor reasons judged by the investigator is allowed for enrollment); active tuberculosis.

Live attenuated vaccine vaccination history within 28 days before the first study drug administration or expected live attenuated vaccine vaccination during the study (including COVID-19 vaccine).

HIV infection or known acquired immunodeficiency syndrome (AIDS).

Active HBV infection (other abnormal HBV serology tests besides hepatitis B surface antibody positive or ≥ ULN, HBV DNA copy number required to confirm activity) and/or HCV infection (HCV RNA copy number required to confirm activity if hepatitis C virus antibody is abnormal).

Major surgery, extensive radiotherapy within 28 days before enrollment, or local palliative radiotherapy within 2 weeks.

Baseline: ≥ G2 peripheral neuropathy; active brain metastases, carcinomatous meningitis, spinal cord compression, or imaging studies (CT or MRI) at screening showing brain or leptomeningeal disease (patients with brain metastases who have completed treatment and stabilized symptoms within 14 days before enrollment are allowed, but must be evaluated by cranial MRI, CT, or venography to confirm no symptoms of cerebral hemorrhage).

Factors significantly affecting oral drug absorption, such as inability to swallow, history of total gastrectomy, short bowel syndrome, or clinically significant intestinal obstruction.

Participants who have received or are preparing to receive allogeneic bone marrow transplantation or organ transplantation.

History of severe allergy, immunostress, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins; hypersensitivity or allergy to any component of Toripalimab injection.

Active autoimmune diseases requiring systemic treatment within 2 years before the first administration of the study drug. Replacement therapy is not considered systemic treatment.

Diagnosed with immunodeficiency or receiving systemic corticosteroid treatment or any form of immunosuppressive therapy, and continuing to use within 2 weeks before the first administration of the study drug.

Pregnant, breastfeeding, or planning to become pregnant during the study. 5. Other serious physical or mental illnesses or laboratory test abnormalities that may increase the risk of participating in the study, interfere with study results, or patients deemed unsuitable for the study by the investigator.