Patients must meet all the following inclusion criteria:

Biological male at birth ≥ 21 years of age

Histopathological confirmed prostate adenocarcinoma

Patients meeting the enrollment criteria for either Cohort 1 or Cohort 2: 1. Cohort 1: * Patients who are newly diagnosed with prostate cancer (and have suspected metastases per the physician's discretion per standard of care assessment) and have not yet initiated any prostate cancer treatment and are referred to undergo PYLARIFY PET for identification of suspected metastases. * OR 2. Cohort 2: * Patients who have previously received treatment for prostate cancer and are referred to undergo PYLARIFY PET or have received PYLARIFY PET for suspected recurrence of prostate cancer (based on an elevated PSA) within 60 days of consent to enroll in the registry

Life expectancy ≥ 6 months as determined by the investigator

Able and willing to provide informed consent and comply with the protocol requirements.

Patients meeting any of the following exclusion criteria are not eligible for enrollment in this study:

Patients who are referred for PSMA PET and undergo a PSMA PET with a radioactive agent other than PYLARIFY

Patients who have histological evidence of neuroendocrine prostate cancer (NEPC) (small cell/ductal variant)

Patients with any medical condition or other circumstances that, in the opinion of the investigator, compromise the safety of compliance of the patient to produce reliable data or completing the study.