Any gender, race, or ethnicity is acceptable

Must be at least 18 years of age

All subjects must fall into the following group:

All Cases will be classified as following cohorts

Cohort lung cancer - Subject must meet the following criteria:

Recently diagnosed advanced lung cancer

Locally advanced and metastatic solid tumors

Treatment naïve (not yet treated or tumor removed; biopsy acceptable) and/or on treatment

Previously Treated: If treated, must have developed resistance and testing will be looking at change in therapy based on results of testing

Gyn malignancies (list ovarian and uterine cancer separately)

Recently diagnosed advanced gynecological malignancies

Locally advanced and metastatic solid tumors

Treatment naïve (not yet treated or tumor removed; biopsy acceptable).

Previously Treated: If treated, must have developed resistance and testing will be looking at change in therapy based on results of testing

Gastrointestinal malignancies Cohort (list all cancers separately-colorectal, gastric, esophageal and pancreatic)

Recently diagnosed advanced gastrointestinal malignancy

Locally advanced and metastatic solid tumors

Treatment naïve (not yet treated or tumor removed; biopsy acceptable).

Previously Treated: If treated, must have developed resistance and testing will be looking at change in therapy based on results of testing

Melanoma Cohort

Recently diagnosed advanced melanoma

Locally advanced and metastatic solid tumors

Treatment naïve (not yet treated or tumor removed; biopsy acceptable).

Previously Treated: If treated, must have developed resistance and testing will be looking at change in therapy based on results of testing

Breast cancer Cohort

Recently diagnosed advanced breast cancer

Locally advanced and metastatic solid tumors

Treatment naïve (not yet treated or tumor removed; biopsy acceptable).

Previously Treated: If treated, must have developed resistance and testing will be looking at change in therapy based on results of testing

Head and neck cancer Cohort

Recently diagnosed advanced head and neck cancer

Locally advanced and metastatic solid tumors

Treatment naïve (not yet treated or tumor removed; biopsy acceptable).

Previously Treated: If treated, must have developed resistance and testing will be looking at change in therapy based on results of testing

Sarcoma and soft tissue cancer cohort

Recently diagnosed advanced cancer

Locally advanced and metastatic solid tumors

Treatment naïve (not yet treated or tumor removed; biopsy acceptable).

Previously Treated: If treated, must have developed resistance and testing will be looking at change in therapy based on results of testing

Prostate cancer

Recently diagnosed advanced cancer

Locally advanced and metastatic solid tumors

Treatment naïve (not yet treated or tumor removed; biopsy acceptable).

Previously Treated: If treated, must have developed resistance and testing will be looking at change in therapy based on results of testing

Additional Requirements

Subjects must be diagnosed by appropriate histopathology

Subjects can have any concurrent diseases

Must voluntarily sign and understand the most current Institutional Review Board/Independent Ethics Committee (IRB/IEC) - approved Informed Consent Form (ICF) prior to study participation. Witness must sign the informed consent form if the subject is illiterate.

Subjects incapable of understanding the items listed in the ICF and the consent process

Pregnant females

Subjects with a history of or known psychiatric illness that deems them unable to consent