Back to Search Results- Recruiting
- Treatment
- Interventional
- Randomized
- Behavioral & Drug
- McMaster University
- 45 Years -
Study Purpose
RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a new diagnosis of prostate cancer.
Intervention
Behavioral : Nutrition
Behavioral : Exercise
Behavioral : Smoking cessation
Drug : Statin (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)
Drug : ACE inhibitor
Eligibility Requirements
A man with a diagnosis of prostate cancer that is either:
new (i.e. the diagnosis was made within 1 year of the enrolment visit) or
treated with Androgen Deprivation Therapy for the first time within 6 months prior to the enrolment visit, or
to be treated with Androgen Deprivation Therapy for the first time within 1 month after the enrolment visit
Patients will be excluded if they fulfill any of the following:
1. are unwilling to provide consent or
2. are \<45 years of age, or
3. prostate cancer was found incidentally following cystectomy for bladder cance
Patients will be eligible for RADICAL PC1, but will not be eligible for RADICAL PC2 if they:
1. see a cardiologist every year, or
2. both take a statin and have systolic blood pressure ≤130mmH
Recruiting status
Recruiting
Estimated enrollment
6000
Study start date
Oct 21, 2015
Study end date
Dec 31, 2026
Last updated
Mar 23, 2025
Primary purpose
Treatment
Design
Interventional
Intervention
Behavioral & Drug
Study phase
NA
Allocation
Randomized
Sponsor:
McMaster University
Collaborator:
Prostate Cancer Canada
Canadian Cancer Society (CCS)
Investigator:
Dr. Darryl Leong, MBBs,MPH,PhD,FRACP,FESC
N/A
NCT03127631
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